Three other tree nuts—walnuts, pistachios, and almonds—are currently permitted to make similar heart health claims, and nut consumption is encouraged in the Dietary Guidelines for Americans. The Centers for Disease Control and Prevention identifies heart disease as the leading cause of death for both men and women in the United States. The health benefits attributed to macadamia nuts are associated with their high content of monounsaturated fats, which are known to lower bad cholesterol levels and decrease the risk of heart disease and stroke. Research into the effects of macadamia nuts on reducing LDL cholesterol began in the 1990s, and evidence supporting this positive association has continued to accumulate.

While the recent label claim for macadamia nuts originated from a petition by Royal Hawaiian Orchards, it can be utilized by all macadamia nut suppliers, meaning the company is unlikely to gain a competitive edge over its direct rivals in the industry. Nevertheless, this claim allows macadamia nuts to compete on equal terms with other tree nuts. In 2003, the FDA approved one of the first qualified health claims linking tree nut consumption to a reduced risk of heart disease, but this marks the first instance where manufacturers can specifically highlight the heart health benefits of macadamia nuts.

In addition to promoting heart health, macadamia nuts can be part of a balanced diet that includes essential nutrients like calcium citrate, calcium aspartate, calcium orotate, and vitamin D3 tablets. These nutrients play a crucial role in overall health, and incorporating them alongside macadamia nuts can further enhance their benefits. Thus, the combination of macadamia nuts and these calcium and vitamin D3 sources can contribute to a heart-healthy lifestyle.