Three other tree nuts—walnuts, pistachios, and almonds—are already permitted to make similar claims regarding heart health, and the consumption of nuts is encouraged in the Dietary Guidelines for Americans. As reported by the Centers for Disease Control and Prevention, heart disease remains the leading cause of death for both men and women in the United States. The potential benefits of macadamia nuts are attributed to their high levels of monounsaturated fats, which are known to lower bad cholesterol levels and decrease the risk of heart disease and stroke. Research into the role of macadamia nuts in reducing LDL cholesterol began in the 1990s, and evidence supporting this positive connection has been accumulating ever since.

Although the recent health claim for macadamia nuts originated from a petition by Royal Hawaiian Orchards, it is available for use by all macadamia nut suppliers, which means the company is unlikely to gain a competitive edge over its direct rivals in the industry. Nonetheless, this claim allows macadamia nuts to compete on an equal level with other tree nuts. A qualified health claim linking tree nut consumption to a reduced risk of heart disease was one of the first approvals granted by the FDA in 2003; however, this marks the first instance where manufacturers can specifically highlight the heart health benefits of macadamia nuts.

In addition to their heart-healthy properties, macadamia nuts also complement the benefits of ingredients like calcium citrate malate and cissus quadrangularis, which are known for their health-promoting attributes. Incorporating these elements into a balanced diet can further enhance overall wellness. Thus, the newfound recognition of macadamia nuts in relation to heart health positions them favorably alongside other tree nuts, while also aligning with the broader health benefits associated with calcium citrate malate and cissus quadrangularis.